New glimmer of hope in the fight against psoriasis: study reveals key role from SSAT!

New glimmer of hope in the fight against psoriasis: study reveals key role from SSAT!

A groundbreaking study under the direction of the MedUni Vienna revolutionizes the treatment of psoriasis, also known as psoriasis. This common chronic inflammatory skin disease affects around 250,000 people in Austria. So far, therapies have mainly focused on the inhibition of inflammatory immune cells. However, the new findings published in the respected “Immunity” specialist journal show that it is possible to specifically restore the function of inflammatory regulatory T cells (TREG cells). The research made it clear that the loss of the function of these cells is caused by a false control of the cellular metabolism, as Study Head of Georg Stary explains, who works as an expert in dermatology at the university clinic for the Dermatology of the MedUni Vienna

key role of the enzyme ssat

A central result of the study is the identification of the enzyme SSAT, which is responsible for regulating molecules that control the balance between anti -inflammatory and promoting immune cells. In the event of active SSAT, TREG cells lose their probiotic properties and instead produce inflammation-promoting messenger substances, which reinforces the immune reaction in psoriasis. In order to escape this vicious circle, the research team found that the inhibition of SSAT in the mouse model with psoriasis-like skin inflammation can break through the regulating function of Treg cells восстановить and the inflammatory cycle.

The development of specific active ingredients that inhibit SSAT could be a more promising, low -side effect alternative to existing treatment methods that are often accompanied by an increased susceptibility to infections. The researchers hope that their approach could not only be important for psoriasis, but also for other chronic inflammatory diseases, as Georg Stary finally emphasizes. These innovative approaches bring new hope in the treatment of skin diseases and could significantly improve the quality of life of many affected people, as reported. in addition.

The new research technology and the results open up exciting perspectives in dermatology and could significantly expand the understanding of chronic inflammatory processes. The publication of this study is an important step in the development direction of therapeutic options, which focus on sustainable restoration of the immune functions instead of simply suppressing the immune response. This could not only revolutionize the treatment of psoriasis, but possibly also from other autoimmunes and inflammatory diseases, which is of great importance in future medical research, as described in detail in the study.