Hemophilia: How the blood disease adds biological aging

Hemophilia: How the blood disease adds biological aging

Scientists from MedUni Vienna have shown that people with hemophilia have a significantly accelerated biological aging. In the journal "Haematologica", the researchers explain that despite the increased life expectancy of hemophilia patients, whose biological age is significantly higher than in healthy control persons. In the study, biomarkers such as the telomer length and the number of mitochondrial DNA copies were analyzed and significant differences were found: hemophilia patients show shorter telomeres and reduced mitochondrial DNA, which indicate an accelerated aging, such as ots.at reported.

The research of the team around Cihan Ay and Philipp Hohensinner also showed increased oxidative damage in the DNA of those affected, possibly caused by chronic inflammation as a result of bleeding in the joints. These inflammation seem to play an important role in the biological aging process. The study on this findings emphasizes that understanding biological aging is of great importance in rare innate diseases and further examinations are necessary to clarify the long -term health effects.

body fluids and blood clotting

At the same time, the influence of saliva on blood clotting was examined in another study by MedUni Vienna and Amsterdam University Medical Centers. Researchers around Johannes Thaler discovered that saliva of hemophilia A-patients contains extrinsic tenase complexes that are crucial for the activation of blood clotting. These findings explain why hemophilia patients are less likely to suffer from mouth mucosa bleeding than others. Historical research results, which already emphasized the importance of body fluids for blood clotting in the 1930s, received fresh update through this new study, such as lisavienna.at reported. The researchers are calling for such historical work to develop innovative approaches to hemophilia research and treatment.