Study: Increasing skin infections risk of allergic asthma!
Study: Increasing skin infections risk of allergic asthma!
A current study by the Medical University of Vienna and the Cemm Research Center for Molecular Medicine shows alarming results with regard to the effects of skin infections on the immune system. Research, which was published in the renowned “Science Immunology” journal, examines the consequences of local infection with Staphylococcus Aureus (S. Aureus) and its long -term influence on the immune response in mice. S. Aureus can act as harmless and as a pathogen and play an important role in the development of skin infections.
After an infection with S. Aureus, not only neutrophilic granulocytes, but also eosinophils migrate into the inflamed region. Eosinophils are a kind of white blood cells that are particularly important in allergic diseases. The examination shows that such a skin infection leads to permanent changes in the bone marrow, where eosinophils are produced. These eosinophils, which have been isolated from infected mice, have an inflammatory signature that remains even after the infection has subsided
long -term consequences and allergies
The infected mice developed an increased allergic-induced inflammation in the lungs after they came into contact with house dust mite allergens. In addition to an increased number of eosinophils in the lung tissue, these animals also showed a significantly increased production of allergy -promoting antibodies and a limited lung function. It turned out that the increased immune response is conveyed by the eosinophils from the changed bone marrow.
additional knowledge of asthma and allergies
Research is in line with previous studies that deal with the role of eosinophilic and basophils in asthmatic reactions. Studies have shown that basophiles in the bronchi of asthmatics are less prominent than Eosinophils and mast cells, which occur to a significantly higher dimensions. By comparing bronchial biopsies of atopic and non-atopic subjects, it was found that basophiles are gaining weight, but still under 10% of the eosinophils.
These immune responses are of central importance because they represent the body's defense mechanisms against infections. The adaptive immune response can be triggered by environmental veneers such as pollen or food and lead to allergic reactions. Allergic diseases, especially in the western world, have increased in the past two decades. The influence of environmental factors and genetic predispositions plays an important role in this.
In summary, the current research results indicate that bacterial skin infections not only cause acute reactions, but can also cause long -term changes in the immune system that contribute to the development of allergies and asthma. This illustrates the need for further studies to develop possible therapeutic approaches and to deepen understanding of the connections between skin infections and allergic reactions.For more information, read the full study on OTS , pubMed and PMC .
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| Ort | Wien, Österreich |
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