Stress leads to dangerous variety in cancer cells - new study!
Stress leads to dangerous variety in cancer cells - new study!
research results of the University of Zurich show how stress influences the evolution of cancer cells in real time. With a newly developed microscope method, scientists can now observe live how cancer cells change under different stress factors and develop new genetic variants. These findings were recently published in the journal "Nature".
Districts have discovered that cancer cells not only show short -term reactions under stress, but also go through long -term genetic changes. Stress factors, such as chemical active ingredients that disrupt the DNA doubling, as well as radiation that causes DNA damage, cause the cells to form a wide variety of daughter cells. This increased genetic diversity can significantly increase resistance to therapies, as https://www.vol.at/forschende-bachten-auf- von-stress-krebszellen/9420500) reports.The method of real -time observation
The new microscopy method combines highly developed image segmentation with crispr-based genomediation. Researchers have provided Two proteins with fluorescent markings: one to pursue the DNA doubling and a DNA damage to marking DNA damage. This technology enables cellular heterogeneity to be followed over several cell generations, which was difficult to do before. Merula Stout, a doctoral student of the study and co-ornament of the study, emphasizes that these observations give decisive insights into the adaptation mechanisms of cancer cells.
The study results show that cancer cells no longer behave synchronously in the event of stress. This means that differences in DNA doubles and protein production occur increasingly. Stress has long-term effects on diversity within cell populations, which can promote both the development of diseases such as cancer and adaptation options, such as [bionity.com
explained.consequences and outlook on future therapies
Especially the development of polyploidie, a state in which cells have several copies of their genome, is of interest for research. Polyploidie increases genetic complexity and enables faster adjustments. At the same time, this can be a challenge for the effectiveness of therapies, since the processes that lead to an increased diversity also promote resistance mechanisms against medication. Andreas Panagopoulos, co-orer of the study, emphasizes that understanding of these mechanisms could enable it to better adapt therapies in the future and possibly to influence the development of polyploidie.
With the aim of further expanding and automating the method, the research team points out that a high throughput and large amounts of data are necessary. This modern approach could cause basic changes in the way we understand and combat the development of cancer cells. The combination of innovative technology and comprehensive research results gives hope for new approaches in cancer therapy, such as news.uzh.ch.
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| Ort | Zürich, Schweiz |
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