Focus on intestinal health: New insights into the post-covid syndrome!

Focus on intestinal health: New insights into the post-covid syndrome!

Wien, Österreich - A research team from the Medical University of Vienna has published new insights into post-covid syndrome (PCS) and its connection with gastrointestinal health. The study published in the journal Allergy illuminates how changes in intestinal health are connected to symptoms of post -viral fatigue. According to the results, PCS patients show significant changes in the inflammatory markers and a disturbed intestinal barrier, which indicates the long-term effects of SARS-COV-2 on the immune system. Eva Untersmayr-Elsenhuber was headed by the study, which is active in the Center for Pathophysiology, Infectiology and Immunology.

The examination was made possible by analyzing data from a prospective observation study on SARS-COV-2 infections and gastrointestinal complaints. Blood, saliva and stool samples from PSC patients were evaluated: inside. Pre-existing gastrointestinal complaints proved to be a risk factor for the development of post-viral fatigue. Among the biomarkers identified are an increased LBP/SCD14 ratio, lower IL-33 values ​​and increased IL-6 levels.

Frequency gastrointestinal symptoms

A comprehensive meta-analysis in which 50 studies on the frequency of gastrointestinal symptoms as part of Long Covid have been shown that about 22% of the long-covide patients: inside suffer from GI complaints. The most common symptoms include abdominal pain (14%), nausea/vomiting (6%) and loss of appetite (20%) [ PMC ] These symptoms not only occurred in difficult courses, but also for mild covid-19 diseases.

The heterogeneity of the studies data indicates different manifestations of gastrointestinal phenomena. Study results show that around 10 to 20 percent of SARS-COV-2-infected long-term symptoms develop in terms of several million people worldwide. Research for predisposing factors and biomarkers for PCs for personalized therapy is still underway, whereby the first results from Vienna already point in this direction.

context and involved factors

Post-Covid syndrome, which occurs after more than twelve weeks after the Covid 19 disease, is not defined as a uniform clinical picture. Many organ systems can include the diverse health aftermath. According to the Robert Koch Institute (RKI), the exact number of those affected are not yet reliable. However, younger adults and women are more often affected according to current knowledge. Also existing health problems such as diabetes or cardiovascular diseases increase the risk of post-covid symptoms [ Heiligenfeld ].

Research continues to better understand the long-term effects of COVID-19 and to develop potential treatment strategies. The monitoring of gastrointestinal symptoms and biomarkers could help to identify risk patients at an early stage and to promote targeted treatment approaches. Further studies are planned to validate the latest knowledge and identify predictive markers for PCs.

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OrtWien, Österreich
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